In the ovary, follicle-stimulating hormone (FSH) binds selectively to its own receptor (FSHR) exclusively localized on granulosa cells, resulting in activation of adenosine 3?,5?-cyclic monophosphate (cAMP)-dependent and other cAMP-independent signalling pathways. As a result of these signal transductional pathways, FSH induces changes in the intracellular Ca2+ concentration of granulosa cells which represent a major ovarian [...]